Author Correction: Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
| Autor: | Halvorsen, Matthew, Huh, Ruth, Oskolkov, Nikolay, Wen, Jia, Netotea, Sergiu, Giusti-Rodriguez, Paola, Karlsson, Robert, Bryois, Julien, Nystedt, Björn, Ameur, Adam, Kähler, Anna K., Ancalade, NaEshia, Farrell, Martilias, Crowley, James J., Li, Yun, Magnusson, Patrik K. E., Gyllensten, Ulf, Hultman, Christina M., Sullivan, Patrick F., Szatkiewicz, Jin P. |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Quality Control Genetics of the nervous system Multidisciplinary Genome Human Science Brain High-Throughput Nucleotide Sequencing General Physics and Astronomy Sequence Analysis DNA General Chemistry Nervous System General Biochemistry Genetics and Molecular Biology Next-generation sequencing Schizophrenia Humans Exome DNA sequencing Author Correction Genome-Wide Association Study |
| Zdroj: | Nature Communications Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022) |
| ISSN: | 2041-1723 |
| Popis: | Despite considerable progress in schizophrenia genetics, most findings have been for large rare structural variants and common variants in well-imputed regions with few genes implicated from exome sequencing. Whole genome sequencing (WGS) can potentially provide a more complete enumeration of etiological genetic variation apart from the exome and regions of high linkage disequilibrium. We analyze high-coverage WGS data from 1162 Swedish schizophrenia cases and 936 ancestry-matched population controls. Our main objective is to evaluate the contribution to schizophrenia etiology from a variety of genetic variants accessible to WGS but not by previous technologies. Our results suggest that ultra-rare structural variants that affect the boundaries of topologically associated domains (TADs) increase risk for schizophrenia. Alterations in TAD boundaries may lead to dysregulation of gene expression. Future mechanistic studies will be needed to determine the precise functional effects of these variants on biology. |
| Databáze: | OpenAIRE |
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