Prefrontal cortical control of a brainstem social behavior circuit
| Autor: | Tiago Branco, Tamara B. Franklin, Valery Grinevich, Bianca A. Silva, Violaine Verrechia, Alexei L. Vyssotski, Livia Marrone, Angie Kaplan, Sara Pagella, Maria Esteban Masferrer, Anna Illarianova, Zinaida Perova, Louise Greetham, Andreas Halman, Yang Zhan, Cornelius Gross |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Prefrontal Cortex Periaqueductal gray Article Social defeat 03 medical and health sciences Mice 0302 clinical medicine Neural Pathways Biological neural network Animals Periaqueductal Gray Prefrontal cortex Social Behavior Self-reference effect Behavior Animal General Neuroscience Mice Inbred C57BL 030104 developmental biology Synaptic plasticity Models Animal Brainstem Consumer neuroscience Psychology Neuroscience 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 |
| Popis: | Summary The prefrontal cortex plays a critical role in adjusting an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal grey, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior. |
| Databáze: | OpenAIRE |
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