Forms of Circulating Luteinizing Hormone Human Chorionic Gonadotropin Receptor for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy
| Autor: | Elena Casals, Stefania Triunfo, Francesc Figueras, Subhasis Banerjee, Laia Rodriguez-Revenga Bodi, Francesca Crovetto, Eduard Gratacós, Imma Mercadé, Walter E Mills, Anne E. Chambers, Luis Lasalvia, Michael Pugia, Fatima Crispi, Aurea Mira |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Placental growth factor endocrine system Embryology medicine.medical_specialty Preeclampsia Cohort Studies Pre-Eclampsia Predictive Value of Tests Pregnancy medicine.artery medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Uterine artery Prospective cohort study Ultrasonography Gynecology business.industry Obstetrics and Gynecology General Medicine Receptors LH medicine.disease Pregnancy Trimester First Case-Control Studies Pediatrics Perinatology and Child Health Female business Luteinizing hormone Body mass index Biomarkers Soluble fms-like tyrosine kinase-1 |
| Zdroj: | Fetal Diagnosis and Therapy. 38:94-102 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000371516 |
| Popis: | Objective: To explore the value of circulating luteinizing human chorionic gonadotropin receptor (LHCGR) forms for the prediction of preeclampsia (PE) in the first trimester of pregnancy. Methods: Case-control study, based on a cohort of 5,759 pregnancies, including 20 early PE, 20 late PE, and 300 controls. We recorded/measured maternal characteristics, mean arterial pressure (MAP), uterine artery (UtA) Doppler, placental growth factor (PlGF), soluble Fms-like tyrosine kinase-1 (sFtl-1), and LHCGR forms (hCG-LHCGR and soluble LHCGR), and their independent predictive values were analyzed by logistic regression. Results: For early PE, the model included black ethnicity, chronic hypertension, previous PE, MAP, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, achieving detection rates (DR) of 83% at 10% of false-positive rates (FPR) [AUC: 0.961 (95% CI: 0.921-1)]. For late PE, the model included body mass index, previous PE, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, with DR of 75% at 10% of FPR [AUC: 0.923 (95% CI: 0.871-0.976)]. In both early and late PE, LHCGR forms improved DR by 6-15%. Conclusions: LHCGR forms improved the prediction for early and late PE. These results should be confirmed in larger prospective studies. |
| Databáze: | OpenAIRE |
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