Risk of open angle glaucoma due to tumor necrosis factor alpha gene polymorphisms
| Autor: | Leqaa A. Moemen, Tarek M. El-Sergany, Hany Labib, Mona Abd El Hamid, Hazem Helmy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Open angle glaucoma medicine.medical_treatment Population Glaucoma Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine TNFα 308G/A polymorphism Genotype medicine open angle glaucoma education Polymerase chain reaction education.field_of_study lcsh:R5-920 business.industry medicine.disease 030104 developmental biology Cytokine 030221 ophthalmology & optometry Original Article Tumor necrosis factor alpha Restriction fragment length polymorphism business lcsh:Medicine (General) |
| Zdroj: | Electronic Physician, Vol 8, Iss 2, Pp 1978-1983 (2016) Electronic Physician |
| ISSN: | 2008-5842 |
| Popis: | Introduction: Axonal degeneration and retinal ganglion cell apoptosis in glaucoma is associated with tumor necrosis factor alpha (TNF-α), which is an important pro-inflammatory cytokine. The aim of this study was to determine the association between the risk of open angle glaucoma (OAG) in the Egyptian population and tumor necrosis factor alpha (TNF-α) gene polymorphisms. Methods: Sixty OAG patients and 26 healthy unrelated controls were used to analyze TNF-α polymorphism G- 308A using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: the GG genotype was found at a higher frequency in the controls than in the patients, and the AA and GA genotypes were associated strongly with OAG. Conclusion: In this study, we found that the TNF-α polymorphism G-308A was associated significantly with OAG in the Egyptian population. However, there is a need for population-based studies with large numbers of subjects. Also, long-term follow up is required to verify the association between TNF-α polymorphism G-308A and glaucoma susceptibility. |
| Databáze: | OpenAIRE |
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