Photothermal-Chemotherapy Integrated Nanoparticles with Tumor Microenvironment Response Enhanced the Induction of Immunogenic Cell Death for Colorectal Cancer Efficient Treatment
| Autor: | Youcong Gong, Jie Liu, Xu Chen, Yayu Wen, Xufeng Zhu, Xiuying Qin, Guanglong Yuan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
medicine.medical_treatment Metal Nanoparticles 02 engineering and technology 010402 general chemistry 01 natural sciences Mice Immune system Cell Line Tumor medicine Tumor Microenvironment Animals General Materials Science Doxorubicin Tumor microenvironment Drug Carriers Cell Death Immunogenicity technology industry and agriculture Immunotherapy Hyperthermia Induced Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology 0104 chemical sciences Cancer cell Cancer research Immunogenic cell death 0210 nano-technology Colorectal Neoplasms Palladium medicine.drug |
| Zdroj: | ACS applied materialsinterfaces. 11(46) |
| ISSN: | 1944-8252 |
| Popis: | Inducing immunogenic cell death (ICD) that enhances the immunogenicity of dead cancer cells is a new strategy for tumor immunotherapy, but efficiently triggering ICD is the biggest obstacle to achieving this strategy, especially for distant and deep-seated tumors. Here, a new therapeutic system (Pd-Dox@TGMs NPs) that can effectively trigger ICD by combining chemotherapy and photothermal therapy was designed. The nanosystem was fabricated by integrating doxorubicin (Dox) and a photothermal reagent palladium nanoparticles (Pd NPs) into amphiphile triglycerol monostearates (TGMs), which showed specific accumulation, deep penetration, and activation in response to the tumoral enzymatic microenvironment. It was proved that codelivery of Dox and Pd NPs not only effectively killed CT26 cells through chemotherapy and photothermal therapy but also promoted the release of dangerous signaling molecules, such as high mobility group box 1, calreticulin, and adenosine triphosphate, improving the immunogenicity of dead tumor cells. The effective ICD induction mediated by Pd-Dox@TGMs NPs boosted the PD-L1 checkpoint blockade effect, which efficiently improved the infiltration of toxic T lymphocytes at the tumor site and showed excellent tumor treatment effects to both primary and abscopal tumors. Therefore, this work provides a simple and effective immunotherapeutic strategy by combining chemical-photothermal therapy to enhance immune response. |
| Databáze: | OpenAIRE |
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