Platelet aggregation induced by antilymphocyte serum. I. Differences between washed and unwashed platelets
| Autor: | Clara V. Hussey, John C. Garancis, Teh Yu Wang, Jane E. Fobian |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Blood Platelets
Lysis Platelet aggregation Platelet Aggregation Mersalyl Tetanus Antitoxin chemistry.chemical_compound Calcium Chloride Adenosine Triphosphate medicine Animals Humans Nucleotide Platelet Magnesium Horses Prostaglandin E1 Edetic Acid Antilymphocyte Serum chemistry.chemical_classification Aspirin Heparin Goats Prostaglandins E General Medicine Complement C3 Adenosine Diphosphate Cytolysis chemistry Biochemistry medicine.drug |
| Zdroj: | American journal of clinical pathology. 64(5) |
| ISSN: | 0002-9173 |
| Popis: | Horse antilymphocyte serum (ALS) induced active release of nucleotides and aggregation of washed human platelets. It also caused lysis of platelets in the presence of plasma. The sequence of lytic processes was studied by electron microscopy. Aggregation induced by ALS was not mediated through ADP in either washed or unwashed platelets, but was inhibited by those inhibitors of secondary platelet aggregation. In unwashed platelets heparin inhibited the cytolysis and aggregation completely, while prostaglandin E1 (PGE1) did not; in contrast, PGE1 completely inhibited the aggregation and release of nucleotides from washed platelets, while heparin did not. The possible mechanisms of ALS-induced aggregation are discussed. |
| Databáze: | OpenAIRE |
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