The use of collagen-based matrices in the treatment of full-thickness wounds
| Autor: | Gunnar Hübner, Jens Rothenberger, Manuel Held, Hans-Eberhard Schaller, Jan-Ole Werner, Jennifer Lynn Schiefer, Wiebke Petersen, Afshin Rahmanian-Schwarz |
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| Rok vydání: | 2016 |
| Předmět: |
Scaffold
medicine.medical_specialty Swine 02 engineering and technology Critical Care and Intensive Care Medicine Random Allocation 03 medical and health sciences 0302 clinical medicine Cell density medicine Animals 030212 general & internal medicine Wound Healing Tissue Scaffolds integumentary system business.industry Multiple applications Single application Biomaterial Dermis General Medicine 021001 nanoscience & nanotechnology Skin transplantation Elastin Surgery Emergency Medicine Gelatin Swine Miniature Wounds and Injuries Full thickness Collagen Epidermis 0210 nano-technology Wound healing business Biomedical engineering |
| Zdroj: | Burns. 42:1257-1264 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/j.burns.2016.03.017 |
| Popis: | Chronic and complex full-thickness wounds have become increasingly prevalent. Besides autologous skin transplantation, innovative wound dressing products have gained interest, as the functional and esthetic outcome is still limited. In this respect, the effect of a novel modifiable collagen-gelatin fleece on the healing of deep dermal wounds was examined and compared with untreated controls and Matriderm(®). A total of 48 full-thickness skin defects were generated on six minipigs and treated with the novel collagen-gelatin fleece of different thicknesses in single or multiple application (n=36) or treated with Matriderm(®) in a single application (n=6), or the wounds were left untreated (n=6). Wound healing was analyzed planimetrically by wound closure per time and histologically with regard to epidermal thickness and cell density. Compared to untreated wounds, wound closure per time and histological skin quality with regard to the mean epidermal thickness and epidermal cell amount were enhanced in both treatment groups. Overall, the best results for the novel collagen-gelatin fleece were achieved for multiple applications with a thickness of 150g/m(2). The novel biomaterial shows accelerated and improved dermal wound repair in a minipig model. As the manufacturing process of the scaffold allows the integration of bioactive substances such as antibiotics and growth factors, we intend to design a composite biomaterial using this scaffold as a carrier matrix. |
| Databáze: | OpenAIRE |
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