Clinical validity of a gene expression signature in diagnostically uncertain neoplasms
| Autor: | Stephanie Meek, Loren E. Clarke, Michael T. Tetzlaff, Lyn M. Duncan, Patricia Vitale, David E. Elder, David S. Cassarino, Whitney A. High, Karl M Napekoski, Darl D. Flake, Brent Mabey, Victor G. Prieto |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Expression Signature Diagnostic accuracy Test sensitivity Sensitivity and Specificity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor Humans Medicine Gene Regulatory Networks Medical diagnosis Melanoma Early Detection of Cancer Aged Retrospective Studies Pharmacology Reverse Transcriptase Polymerase Chain Reaction business.industry Gene Expression Profiling General Medicine Middle Aged Gene Expression Regulation Neoplastic Case-Control Studies 030220 oncology & carcinogenesis Clinical validity Molecular Medicine Female business |
| Zdroj: | Personalized Medicine. 17:361-371 |
| ISSN: | 1744-828X 1741-0541 |
| Popis: | Aim: Evaluate the accuracy of a 23-gene expression signature in differentiating benign nevi from melanoma by comparing test results with clinical outcomes. Materials & methods: Seven dermatopathologists blinded to gene expression test results and clinical outcomes examined 181 lesions to identify diagnostically uncertain cases. Participants independently recorded diagnoses and responses to questions quantifying diagnostic certainty. Test accuracy was determined through comparison with clinical outcomes (sensitivity and percent negative agreement). Results: Overall, 125 cases fulfilled criteria for diagnostic uncertainty (69.1%; 95% CI: 61.8–75.7%). Test sensitivity and percent negative agreement in these cases were 90.4% (95% CI: 79.0–96.8%) and 95.5% (95% CI: 87.3–99.1%), respectively. Conclusion: The 23-gene expression signature has high diagnostic accuracy in diagnostically uncertain cases when evaluated against clinical outcomes. |
| Databáze: | OpenAIRE |
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