The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response
| Autor: | Alexandre H.C. Marques, Dennyson Leandro M. Fonseca, Hans D. Ochs, Desiree Rodrigues Placa, Lena F. Schimke, Otavio Cabral-Marques, Niels Olsen Saraiva Camara, Ranieri Coelho Salgado, Antonio Condino-Neto, Igor Salerno Filgueiras, Gabriel Jansen-Marques, Gustavo Cabral de Miranda, Roberta De Vito, Gabriela Crispim Baiocchi, Karen Tiemi Akashi, Sarah Maria da Silva Napoleao, Igor Jurisica, Caroline Aliane de Souza Prado, Vera Lúcia Garcia Calich, Tabata Takahashi França, Paula Paccielli Freire |
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| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
Candida parapsilosis Transcription Genetic Microarray Science Immunology Diseases Candida glabrata Biology Antiviral Agents Article Transcriptome Medical research Immune system Interferon Gene Expression Regulation Fungal Candida albicans Databases Genetic medicine Humans TRANSCRIÇÃO GÊNICA RNA-Seq Receptor Toll-like receptor Multidisciplinary Gene Expression Profiling Candidiasis Immunity Computational Biology Immunity Innate Medicine Interferons Signal transduction Signal Transduction medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Fungal infections represent a major global health problem affecting over a billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of the human immune responses to Candida spp. through meta-analysis of microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for the blood transcriptome. We identified across these different studies a consistent interconnected network interplay of signaling molecules involved in both Toll-like receptor (TLR) and interferon (IFN) signaling cascades that is activated in response to different Candida species (C. albicans, C. auris, C. glabrata, C. parapsilosis, and C. tropicalis). Among these molecules are several types I IFN, indicating an overlap with antiviral immune responses. scRNA-seq data confirmed that genes commonly identified by the three transcriptomic methods show cell type-specific expression patterns in various innate and adaptive immune cells. These findings shed new light on the anti-Candida immune response, providing putative molecular pathways for therapeutic intervention. |
| Databáze: | OpenAIRE |
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