Selenorhodamine photosensitizers with the Texas-red core for photodynamic therapy of cancer cells
| Autor: | Michael R. Detty, Michelle K. Linder, Tymish Y. Ohulchanskyy, Mark W. Kryman, Kellie S. Davies |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Clinical Biochemistry Pharmaceutical Science Texas Red Photodynamic therapy Absorption (skin) Photochemistry Biochemistry chemistry.chemical_compound Cell Line Tumor Organoselenium Compounds Drug Discovery medicine Humans Molecular Biology Thioamide chemistry.chemical_classification Photosensitizing Agents Singlet Oxygen Rhodamines Singlet oxygen Organic Chemistry Fluorescence digestive system diseases Mitochondria Spectrometry Fluorescence Photochemotherapy Xanthenes chemistry Cancer cell Molecular Medicine Phototoxicity |
| Zdroj: | Bioorganic & Medicinal Chemistry. 23:4501-4507 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2015.06.006 |
| Popis: | We examined two selenorhodamines with amide and thioamide functionality at the 5-position of a 9-(2-thienyl) substituent on the selenoxanthylium analogue of the Texas-red core for their potential as photosensitizers for photodynamic therapy (PDT) in P-glycoprotein (P-gp)-expressing Colo-26 cells. These compounds were examined for their photophysical properties (absorption, fluorescence, and ability to generate singlet oxygen), for their uptake into Colo-26 cells in the absence or presence of verapamil, for their dark and phototoxicity toward Colo-26 cells, and for their co-localization with mitochondrial-specific agents in Colo-26 cells. Both compounds were extremely effective photosensitizers with values of EC50 ⩽ 4 × 10(-8)M toward Colo-26 cells with 1.0 J cm(-2) laser light delivered at 630 ± 2 nm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect