Trypanosome variant surface glycoproteins are recognized by self-reactive antibodies in uninfected hosts
| Autor: | Thomas Seebeck, Norbert Müller, J. M. Mansfield |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Antigenicity
Glycosylation Blotting Western Immunology Antibody Affinity Antibodies Protozoan Cross Reactions Microbiology Epitope Cell Line Epitopes Mice Immune system Antigen Antibody Specificity Animals Humans Autoantibodies Antiserum chemistry.chemical_classification biology biology.organism_classification Virology Mice Inbred C57BL Infectious Diseases chemistry Mice Inbred DBA biology.protein Trypanosoma Cattle Female Parasitology Antibody Glycoprotein Variant Surface Glycoproteins Trypanosoma Research Article |
| Zdroj: | Infection and Immunity. 64:4593-4597 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.64.11.4593-4597.1996 |
| Popis: | The variant surface glycoproteins (VSGs) of African trypanosomes form a dense surface coat on the bloodstream parasites. VSGs are immunodominant antigens that stimulate a rapid antibody response in trypanosome-infected individuals. In the present study, we examined VSG-specific antibodies present not only in sera from infected individuals but also in sera from individuals that had never been exposed to trypanosomes. Native antibodies against different VSGs were detected in sera from uninfected mice, bovines, and humans; the antibodies were revealed to be exclusively directed against variable determinants of the antigens. Further experimentation demonstrated that such native antibodies immunoreact with cellular components of mice and thus are most likely produced by the self-reactive B-cell compartment of the murine immune system. |
| Databáze: | OpenAIRE |
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