Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
| Autor: | Karen A. Lillycrop, Mark A. Hanson, Paul A. Townsend, Graham C. Burdge, Joanne L. Slater-Jefferies, Samuel P. Hoile |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty food.ingredient Heart disease Clinical Biochemistry Phospholipid Biology Triacylglycerol Article Soybean oil chemistry.chemical_compound Sex Factors food Internal medicine Phophospholipids medicine Animals Weaning Rats Wistar Fatty acids Phospholipids Triglycerides Myocardium Heart Cell Biology medicine.disease Dietary Fats Rats Endocrinology chemistry Dietary fat intake Circulatory system Phosphatidylcholines Rat Female Sex lipids (amino acids peptides and proteins) Composition (visual arts) Fatty acid composition |
| Zdroj: | Prostaglandins, Leukotrienes, and Essential Fatty Acids |
| ISSN: | 0952-3278 |
| Popis: | Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. |
| Databáze: | OpenAIRE |
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