Evidence for the polymorphic oxidation of debrisoquine and proguanil in a New Zealand Maori population
| Autor: | J.R. Denton, P A Barron, J.R. Broughton, S C W Chalcroft, Sompon Wanwimolruk, E L Pratt |
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| Rok vydání: | 1995 |
| Předmět: |
Cycloguanil
Adult Male Adolescent Proguanil White People chemistry.chemical_compound Genetics medicine Ethnicity Humans Maori Population General Pharmacology Toxicology and Pharmaceutics Biotransformation Polymorphism Genetic business.industry Incidence (epidemiology) Middle Aged Debrisoquin Debrisoquine chemistry Poor metabolizer Female business medicine.drug Demography New Zealand |
| Zdroj: | Pharmacogenetics. 5(4) |
| ISSN: | 0960-314X |
| Popis: | The genetic oxidation polymorphisms of debrisoquine and proguanil were studied in a New Zealand Maori population. A bimodal distribution was observed in the 0-4 h urinary debrisoquine/4-hydroxydebrisoquine metabolic ratio. Of 101 Maori subjects phenotyped, five subjects (5%) were identified as poor metabolizers of debrisoquine, according to criteria established in studies of Caucasian populations. The prevalence of the debrisoquine poor metabolizer phenotype in the Maori appears to be similar to that reported for the Caucasian populations, but higher than that found in Asian (non-Caucasian) populations. The distribution of proguanil:cycloguanil (PG:CG) ratios obtained from 43 Maori subjects was highly skewed. Using a PG:CG ratio of 10 as the cut-off point, three Maori subjects (7%) were classified as poor metabolizers of proguanil. The incidence of the poor metabolizer phenotype of proguanil oxidation of 7% seems to be higher in Maori compared with Caucasian populations, but this is lower than the usual ranges (13-35%) reported in Asian populations. |
| Databáze: | OpenAIRE |
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