18F-FDG brain PET hypometabolism in patients with long COVID

Autor: Paul Habert, Didier Raoult, Hervé Tissot-Dupont, Eric Guedj, F. Barthelemy, Matthieu Million, Jacques-Yves Campion, Mathieu Ceccaldi, Serge Cammilleri, Elsa Kaphan, S. Guis, Fabienne Brégeon, Pierre Dudouet, Carole Eldin
Přispěvatelé: Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Service de Neurologie, Hôpital de la Timone, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Interventionnelle Expérimentale (LIIE), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), COMBE, Isabelle, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Hippocampus
Paralimbic cortex
Gastroenterology
030218 nuclear medicine & medical imaging
0302 clinical medicine
Hyposmia
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Fatigue
ComputingMilieux_MISCELLANEOUS
Complaints
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
Brain
General Medicine
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
Nasal decongestant
medicine.anatomical_structure
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Original Article
medicine.symptom
[SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
medicine.medical_specialty
Long COVID
Anosmia
Orbital gyri
Context (language use)
Stress
03 medical and health sciences
Post-Acute COVID-19 Syndrome
Angiotensin-converting enzyme
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Memory
Fluorodeoxyglucose F18
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Olfactory Region
SARS-CoV-2
business.industry
COVID-19
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Dysautonomia
18F-FDG
PET
Positron-Emission Tomography
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
business
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2021, ⟨10.1007/s00259-021-05215-4⟩
European Journal of Nuclear Medicine and Molecular Imaging, 2021, ⟨10.1007/s00259-021-05215-4⟩
ISSN: 1619-7070
1619-7089
DOI: 10.1007/s00259-021-05215-4⟩
Popis: Purpose In the context of the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some patients report functional complaints after apparent recovery from COVID-19. This clinical presentation has been referred as “long COVID.” We here present a retrospective analysis of 18F-FDG brain PET of long COVID patients from the same center with a biologically confirmed diagnosis of SARS-CoV-2 infection and persistent functional complaints at least 3 weeks after the initial infection. Methods PET scans of 35 patients with long COVID were compared using whole-brain voxel-based analysis to a local database of 44 healthy subjects controlled for age and sex to characterize cerebral hypometabolism. The individual relevance of this metabolic profile was evaluated to classify patients and healthy subjects. Finally, the PET abnormalities were exploratory compared with the patients’ characteristics and functional complaints. Results In comparison to healthy subjects, patients with long COVID exhibited bilateral hypometabolism in the bilateral rectal/orbital gyrus, including the olfactory gyrus; the right temporal lobe, including the amygdala and the hippocampus, extending to the right thalamus; the bilateral pons/medulla brainstem; the bilateral cerebellum (p-voxel
Databáze: OpenAIRE
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