O'nyong-nyong fever in south-central Uganda, 1996-1997: description of the epidemic and results of a household-based seroprevalence survey
| Autor: | Margaret Lamunu, George Bagambisa, Robinah Najjemba, Julius J. Lutwama, Willy A. Were, Noah Kiwanuka, Freddie Ssengooba, Jun Kawamata, Grant L. Campbell, Eduard J. Sanders, Elly B. Rwaguma |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Adolescent Alphavirus Disease cluster Antibodies Viral Serology Disease Outbreaks Age Distribution Seroepidemiologic Studies Immunology and Allergy Seroprevalence Medicine Humans Uganda Child Aged Aged 80 and over business.industry Alphavirus Infections Kijanebalola Febrile illness Middle Aged Virology Infectious Diseases Inapparent Infection Child Preschool Female business Demography |
| Zdroj: | The Journal of infectious diseases. 180(5) |
| ISSN: | 0022-1899 |
| Popis: | O'nyong-nyong (ONN) fever, an acute, nonfatal illness characterized by polyarthralgia, is caused by infection with a mosquito-borne central African alphavirus. During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. During January and early February 1997, active case-finding and a household cluster serosurvey were conducted in two affected and two comparison areas. A confirmed case was defined as an acute febrile illness with polyarthralgia occurring within the previous 9 months plus serologic confirmation or isolation of ONN virus from blood. In affected (n = 129) and comparison (n = 115) areas, the estimated infection rates were 45% and 3%, respectively, and the estimated attack rates were 29% and 0%, respectively, for an apparent : inapparent infection ratio of nearly 2 in affected areas. In villages sampled near Lake Kijanebalola, Rakai District, the estimated infection and attack rates were 68% and 41%, respectively, and 55% of sampled households had ≥1 case of ONN fever. In conclusion, this epidemic was focused near lakes and swamps, where it was associated with high infection and attack rates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|