Immunohistochemical localization of metal binding proteins in thyroid tissues and tumors
| Autor: | Sylvia L. Asa, Simon J. Raphael |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases biology Lactoferrin business.industry Endocrinology Diabetes and Metabolism Thyroid General Medicine medicine.disease Follicular cell Pathology and Forensic Medicine Thyroid carcinoma stomatognathic diseases Endocrinology medicine.anatomical_structure medicine biology.protein Immunohistochemistry business Ceruloplasmin Thyroid cancer Immunostaining |
| Zdroj: | Endocrine Pathology. 3:182-187 |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/bf02921360 |
| Popis: | Positive immunohistochemical staining for three metal binding proteins, ceruloplasmin, lactoferrin, and transferrin, has been suggested to be a reliable diagnostic marker of malignant but not benign thyroid neoplasms. We tested this hypothesis on a series of 9 nodular hyperplasias, 17 follicular adenomas, 54 papillary carcinomas, 20 follicular carcinomas, and 3 anaplastic carcinomas of thyroid using formalin-fixed paraffin-embedded tissues. We found focal staining for ceruloplasmin and lactoferrin in approximately 25% of follicular adenomas examined; focal ceruloplasmin positivity was also seen in nonneoplastic tissues surrounding thyroid neoplasms. No staining for these markers was found in malignant neoplasms or hyperplasias. Transferrin was found in 55% of papillary carcinomas, but more follicular adenomas (20%) than follicular carcinomas (11%) were positive using this antiserum. These findings show that immunostaining for these antigens is not a reliable method to distinguish benign from malignant thyroid lesions of follicular cell origin. |
| Databáze: | OpenAIRE |
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