The Relationship Between Changes in Tumour Volume, Tumour Cell Density and Parenchymal Cord Radius in a Human Melanoma Xenograft Exposed to Single Dose Irradiation
| Autor: | Falkvoll Kh |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cord Ratón medicine.medical_treatment Transplantation Heterologous Mice Nude Cell Count Mice Necrosis Parenchyma Animals Humans Medicine Radiology Nuclear Medicine and imaging Melanoma business.industry Dose-Response Relationship Radiation Hematology General Medicine medicine.disease Pathophysiology Radiation therapy Endothelial stem cell Oncology Giant cell Female business Nuclear medicine Cell Division Neoplasm Transplantation |
| Zdroj: | Acta Oncologica. 29:935-939 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869009096393 |
| Popis: | A human melanoma xenograft, in which the viable tumour tissue formed cylindrical cuffs around blood vessels, was irradiated with single doses of 7.5 Gy and 15.0 Gy respectively. The nuclear density, the frequency of giant cells and the mean par-enchymal cord radius were measured and compared to the tumour growth response. After 7.5 Gy, the growth rate was only slightly reduced and there were no significant changes in the nuclear density or the mean parenchymal cord radius. After 15.0 Gy the mean parenchymal cord radius decreased the first week. This coincided with swelling of endothelial cell nuclei and reduced density of functional capillary-like vessels. Although the number of tumour cells declined, the tumour volume increased the first days after irradiation with 15.0 Gy since the cell density was reduced. |
| Databáze: | OpenAIRE |
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