T-Cell Responses Against Mycobacterium ulcerans and Mycobacterium tuberculosis Protein Extracts Identify Children With Buruli Ulcer Disease

Autor: Marc Jacobsen, Jonathan Kofi Adjei, Wilfred Aniagyei, Ernest Adankwah, Julia Seyfarth, Ertan Mayatepek, Daniel Antwi-Berko, Samuel Asamoah Sakyi, Alexander Y Debrah, Linda Batsa Debrah, Dorcas O Owusu, Richard O Phillips
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Pediatric Infectious Diseases Society. 11:575-577
ISSN: 2048-7207
Popis: Immune-based diagnosis of Buruli ulcer disease (BUD) in children is difficult due to cross-reactivity between mycobacteria. We found that T-cell IFNγ/TNFα responses against Mycobacterium (M.) ulcerans and M. tuberculosis (PPDMulc, PPDMtub) were different between children with BUD (n = 27) and TB (n = 20) but only ratios (PPDMtub/PPDMulc) discriminated the study groups efficiently.
Databáze: OpenAIRE
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