The Effects of Lithium Administration on Oxidant/Antioxidant Status in Rats: Biochemical and Histomorphological Evaluations
| Autor: | Nuran Dariyerli, Derviş Özçelik, Selmin Toplan, Gamze Tanriverdi, Semra Özdemir, M. Can Akyolcu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Liver Cirrhosis Male medicine.medical_specialty Lithium (medication) Endocrinology Diabetes and Metabolism Clinical Biochemistry medicine.disease_cause Kidney Biochemistry Inorganic Chemistry Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Lithium Carbonate Internal medicine medicine Animals Rats Wistar biology Dose-Response Relationship Drug Biochemistry (medical) Lithium carbonate General Medicine Glutathione Malondialdehyde Antidepressive Agents 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Liver biology.protein Lipid Peroxidation Oxidative stress medicine.drug |
| Zdroj: | Biological trace element research. 169(2) |
| ISSN: | 1559-0720 |
| Popis: | Present study was planned to determine possible dose-dependent effects of lithium (Li) on oxidant-antioxidant status and histomorphological changes in liver and kidney tissues. For this purpose, twenty-four Wistar male rats were equally divided into three groups: the rats in group I served as controls, drinking tap water without lithium. Groups II and III received 0.1 and 0.2 % lithium carbonate (Li2CO3) through their drinking water, respectively, for 30 days. At the end of the experimental period, lithium concentrations, levels of malondialdehyde (MDA) and glutathione (GSH) and superoxide dismutase (SOD) activities were measured in considered tissues. Histomorphological study was also performed on liver and kidney tissues. Compared to controls, MDA was significantly higher but GSH level lower in groups II and III. SOD activity was higher in group III, but no difference was determined in group II in liver tissue. In kidney tissue, there was no difference determined in MDA and GSH levels between control and experimental groups but SOD activity in groups II and III was significantly higher. In histologic sections of both experimental liver and kidney tissues, specific degenerations were observed. The results of the present study show that treatment with lithium carbonate may result in liver and kidney tissue abnormalities and oxidative damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink