Monosodium glutamate exposure during the neonatal period leads to cognitive deficits in adult Sprague-Dawley rats
| Autor: | Qiong Feng, Gong-Ping Liu, Li Lin, Jianjun Liu, Wei Wang, Dong-Sheng Sun, Sha Liu, Qun Wang, Dan-Ju Luo, Guo-Yong Li, Xifei Yang, Dan Ke, Li Jin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Dendritic spine endocrine system diseases Monosodium glutamate Period (gene) Disease Hippocampal formation Diabetes Mellitus Experimental Rats Sprague-Dawley Pathogenesis 03 medical and health sciences Subcutaneous injection chemistry.chemical_compound 0302 clinical medicine Alzheimer Disease Internal medicine Sodium Glutamate Animals Medicine Cognitive Dysfunction Maze Learning business.industry General Neuroscience Age Factors nutritional and metabolic diseases Type 2 Diabetes Mellitus Rats Flavoring Agents 030104 developmental biology Endocrinology Animals Newborn chemistry business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 682:39-44 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2018.06.008 |
| Popis: | Epidemiological surveys show that 70–80% of patients with Alzheimer’s disease (AD) have type 2 diabetes mellitus (T2DM) or show an abnormality of blood glucose levels. Therefore, an increasing number of evidence has suggested that diabetic hyperglycemia is tightly linked with the pathogenesis and progression of AD. In the present study, we replicated T2DM animal model via subcutaneous injection of newborn Sprague-Dawley (SD) rats with monosodium glutamate (MSG) during the neonatal period to investigate the effects and underlying mechanisms of hyperglycemia on cognitive ability. We found that neonatal MSG exposure induced hyperglycemia as well as Alzheimer-like learning and memory deficits with decreased dendritic spine density and hippocampal synaptic-related protein expression and increased phosphorylated tau levels in ∼3-month-old SD rats. Our results suggested that hyperglycemia probably causes cognitive impairment and Alzheimer-like neuropathological changes, which provide the experimental data connecting T2DM and AD. |
| Databáze: | OpenAIRE |
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