Evaluation of gastrointestinal transit after infection with different loads of Strongyloides venezuelensis in rats
| Autor: | Madileine F. Américo, Ricardo Toshio Fujiwara, Loyane Almeida Gama, Luciana A. Cora, Vitor Luís Tenório Mati, L. Anjos-Ramos |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Veterinary (miscellaneous) 030231 tropical medicine Parasite load Gastroenterology 03 medical and health sciences Cecum Feces 0302 clinical medicine Internal medicine Intestine Small Strongyloides medicine Parasite Egg Count Animals Rats Wistar Gastrointestinal Transit Eggs per gram Gastric emptying biology digestive oral and skin physiology medicine.disease biology.organism_classification Rats Disease Models Animal 030104 developmental biology Infectious Diseases Strongyloidiasis medicine.anatomical_structure Insect Science Immunology Parasitology |
| Zdroj: | Acta tropica. 156 |
| ISSN: | 1873-6254 |
| Popis: | The aim was to correlate the gastrointestinal transit profile in rats, evaluated by a biomagnetic technique, in response to infection with different loads of Strongyloides venezuelensis. Eggs per gram, intestinal number of worms and fecundity, and also gastric emptying time, cecum arrival time, small intestinal transit time and stool weight were determined. Assessments occurred at 0 (control), 3, 6, 9, 12, 15, 18 and 21 days post infection (dpi) with three infective loads (400, 2000, and 10,000 L). Gastric emptying was faster (p=0.0001) and the intestinal transit was significantly slower (p=0.001) during the infection time course. Also, linear mixed-effects models showed significantly changes in small intestinal transit after three parasite load over time. Cecum arrival was not influenced by infection time course or parasite load. As indirect effect, stool weight decreased accompanied a strong oviposition peak at 9 dpi in 400 L and 2000 L. In several motor function instances, neuromuscular dysfunction persists after mucosal inflammation has decreased. Our approach could be very helpful to evaluate gastrointestinal motor abnormalities in vivo after parasite infection. Despite parasitological data progressively decreased after 15 dpi, small intestinal transit worse over time and according to burden. |
| Databáze: | OpenAIRE |
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