The role of ABC-transporter gene polymorphisms in chemotherapy induced immunosuppression, a retrospective study in childhood acute lymphoblastic leukaemia
| Autor: | György Fekete, Attila Tordai, András Falus, Hajnalka Andrikovics, Dániel J. Erdélyi, Ilona Galántai, Béla Csókay, Anna Zalka, Edina Magyarosy, Enikő Kámory, Ágnes F. Semsei, Gábor T. Kovács, Csaba Szalai, Gábor Borgulya |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
ATP Binding Cassette Transporter Subfamily B Adolescent Genotype medicine.medical_treatment Immunology Population Organic Anion Transporters Antineoplastic Agents Opportunistic Infections Polymorphism Single Nucleotide Gastroenterology Cohort Studies Leukocytopenia Internal medicine medicine ATP Binding Cassette Transporter Subfamily G Member 2 Humans ATP Binding Cassette Transporter Subfamily B Member 1 Child education Retrospective Studies Chemotherapy education.field_of_study business.industry Haplotype Infant Immunosuppression Precursor Cell Lymphoblastic Leukemia-Lymphoma Chemotherapy regimen Neoplasm Proteins Child Preschool ATP-Binding Cassette Transporters business Pharmacogenetics |
| Zdroj: | Cellular Immunology. 244:121-124 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2007.02.007 |
| Popis: | We examined the association of functional ABCB1 (MDR1) and ABCG2 (BCRP) polymorphisms with acute side effects of chemotherapy. Analyses were performed on clinical data from 138 patients treated with the ALL-BFM-95 protocol implying several substrates of these transporters. ABCB1 3435T>C, 2677G>T/A 1236C>T and ABCG2 421C>A genotypes were determined. A higher proportion of ABCB1 3435TT patients suffered excessive infectious complications than those harbouring at least one C allele (OR = 2.5, p = 0.03) during the whole half-year-long intensive phase of chemotherapy. Weaker associations were calculated when ABCB1 1236T-2677T-3435T haplotype homozygotes were tested against the remaining part of the population (OR = 2.3, p = 0.09). During the reinduction phase of therapy, the occurrence of severe leukocytopenia was similar among ABCB1 genotype groups. The frequency of any toxicities were not shown to differ according to the ABCG2 421C>A genotype. Our data suggest that the ABCB1 3435T>C genotype is associated with the infectious complications of the applied chemotherapy regimen. |
| Databáze: | OpenAIRE |
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