Corneal cross-linking in patients with keratoconus: up to 13 years of follow-up

Autor: Christian Enders, Diana Vogel, Jens Dreyhaupt, Waltraud Wolf, Aylin Garip-Kuebler, Jonathan Hall, Lukas Neuhann, Jens Ulrich Werner
Rok vydání: 2022
Předmět:
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology. 261:1037-1043
ISSN: 1435-702X
0721-832X
Popis: To evaluate long-term safety and efficacy of corneal collagen cross-linking (CXL) in patients with keratoconus up to 13 years.In this mono-centre exploratory study, we included all consecutive patients who underwent CXL in our cornea centre from 01/01/2007 to 12/30/2011 and met the inclusion criteria. CXL was performed in all patients according to the Dresden protocol. Evaluation included best-corrected visual acuity (BCVA), topographic keratometry by Scheimpflug corneal tomography and endothelial cell count (ECC). Follow-up measurements were taken up to 13 years after treatment were compared with baseline values.The study enrolled 168 eyes. The mean age of our patients was 26.3 years ± 7.8 years. A complete topographic dataset was available 1 year postoperatively for 142 eyes, 5 years postoperatively for 105 eyes, 10 years postoperatively for 61 eyes and 13 years postoperatively for 9 eyes. BCVA increased statistically significant after 1 year, 5 years and 10 years and non-significantly after 13 years. All keratometric parameters with exception of posterior astigmatism showed a statistically significant decrease after 1 year, 5 years and 10 years. After 13 years, the decrease was statistically significant only in Kmax, K2 and thinnest cornea. No significant changes in ECC were detected. Three eyes received Re-CXL, none of the eyes received penetrating keratoplasty and no infections occurred in this cohort.CXL can slow down or even stop the progression of keratoconus in the majority of cases. The effect is long-lasting with excellent safety.
Databáze: OpenAIRE
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