Additional file 1 of Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Autor: Yu, Fei, Tan, Weidan, Chen, Zhiquan, Shen, Xiaoju, Mo, Xiaoxiang, Mo, Xiaocheng, He, Jingchuan, Deng, Zhihua, Wang, Jie, Luo, Zhuo, Yang, Jie
Rok vydání: 2022
DOI: 10.6084/m9.figshare.21251872.v1
Popis: Additional file 1: Table S1 The overlapped targets between NC and lung cancer. Fig. S1 A–C GSDMC, GSDMD and GSDME protein expression were analyzed by Western blotting. D WB analyses of GSDMC, GSDMD and GSDME in lung cancer cell lines and BEAS-2B cell line. Protein levels are expressed as mean ± SD (n=3). Fig. S2 H1688 or A549 cells were transfected with siRNA targeting caspase 3 (siRNA-cas3-1/2/3) or control siRNA for 24 h. Fig. S3 A Body weight of H1688 xenograft mice during the 20 days’ treament (presented as mean ± SD, n=5). B HE of hearts, livers, spleens, lungs, kidneys and tumors at the end of experiment. Scale bar=50 μm. Fig. S4 A Body weight of A549 xenograft mice during the 20 days’ treament (presented as mean±SD, n=5). B HE of hearts, livers, spleens, lungs, kidneys and tumors at the end of experiment. Scale bar=50 μm.
Databáze: OpenAIRE