Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells
| Autor: | Kiyoshi Kano, Masato Hiyama, Ken Takeshi Kusakabe, Nobue Kuniyoshi, Satoko Sugimoto, Shinji Sugi, Shoichi Wakitani, Ai Takeshita, Kazuhiko Hayashi, Yasuo Kiso |
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| Rok vydání: | 2014 |
| Předmět: |
placenta
Cellular differentiation Uterus Biology Immunoglobulin E Dermatitis Atopic Mice Pregnancy NC/Nga mouse Placenta medicine Animals Fetus General Veterinary Reproduction Histological Techniques Placentation Cell Differentiation Atopic dermatitis Note medicine.disease Killer Cells Natural medicine.anatomical_structure uNK cell embryonic structures Immunology biology.protein atopic disease Female Anatomy |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance. |
| Databáze: | OpenAIRE |
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