Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal
| Autor: | Andrey Y. Abramov, Ilya Y. Teplov, A. V. Berezhnov, E. I. Fedotova, A. I. Sergeev |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Physiology Dopamine chemistry.chemical_element Stimulation Calcium GABA Antagonists Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate 0302 clinical medicine Receptors GABA Chloride Channels medicine Animals Calcium Signaling Receptor Bifemelane Neurotransmitter Molecular Biology Cells Cultured Neurons Receptors Dopamine D2 Receptors Dopamine D1 Cell Biology Receptors Adrenergic 030104 developmental biology medicine.anatomical_structure nervous system chemistry Astrocytes Dopamine Agonists Neuron Ion Channel Gating Neuroscience 030217 neurology & neurosurgery medicine.drug Astrocyte |
| Zdroj: | Cell Calcium. 94:102359 |
| ISSN: | 0143-4160 |
| DOI: | 10.1016/j.ceca.2021.102359 |
| Popis: | Dopamine is a neuromodulator and neurotransmitter responsible for a number of physiological processes. Dysfunctions of the dopamine metabolism and signalling are associated with neurological and psychiatric diseases. Here we report that in primary co-culture of neurons and astrocytes dopamine-induces calcium signal in astrocytes and suppress spontaneous synchronous calcium oscillations (SSCO) in neurons. Effect of dopamine on SSCO in neurons was dependent on calcium signal in astrocytes and could be modified by inhibition of dopamine-induced calcium signal or by stimulation of astrocytic calcium rise with ATP. Ability of dopamine to suppress SSCO in neurons was independent on D1- or D2- like receptors but dependent on GABA and alpha-adrenoreceptors. Inhibitor of monoaminoxidase bifemelane blocked effect of dopamine on astrocytes but also inhibited the effect dopamine on SSCO in neurons. These findings suggest that dopamine-induced calcium signal may stimulate release of neuromodulators such as GABA and adrenaline and thus suppress spontaneous calcium oscillations in neurons. |
| Databáze: | OpenAIRE |
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