Lysyl oxidase isoforms in gastric cancer
| Autor: | Carolina Añazco, Jacqueline Romero, Fernando Delgado-López, Erik Morales, Armando Rojas, Paulina Araya, Ramón Pérez-Castro, Ileana Gonzalez |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gene isoform Clinical Biochemistry Lysyl oxidase Extracellular matrix Protein-Lysine 6-Oxidase 03 medical and health sciences 0302 clinical medicine Fibrosis Stomach Neoplasms Drug Discovery medicine Biomarkers Tumor Humans Protein Isoforms Neoplasm Metastasis Chelating Agents Basement membrane chemistry.chemical_classification biology Biochemistry (medical) Cancer Helicobacter pylori biology.organism_classification medicine.disease Elastin 030104 developmental biology medicine.anatomical_structure Enzyme Biochemistry chemistry 030220 oncology & carcinogenesis Cancer research Collagen |
| Zdroj: | Biomarkers in medicine. 10(9) |
| ISSN: | 1752-0371 |
| Popis: | Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in GC. In this review, we focus on the expression levels of lysyl oxidase isoforms, its functions and the clinical implications in GC. Finding novel proteins related to the processing of these extracellular matrix enzymes might be helpful in the design of new therapies, which, in combination with classic pharmacology, could be used to delay the progress of this aggressive cancer and offer a wider temporal window for clinical intervention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|