Genetic factors influencing the outcome of early arthritis--the role of sulphoxidation status
| Autor: | H. Bradley, E. Tunn, V. Arthur, Rosemary H. Waring, Paul Emery |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Disease Asymptomatic Arthritis Rheumatoid Rheumatology Internal medicine medicine Humans Pharmacology (medical) In patient Risk factor Recent onset Autoimmune disease Chi-Square Distribution business.industry Carbocysteine medicine.disease Prognosis Rheumatoid arthritis Sulfoxides Immunology medicine.symptom business Oxidation-Reduction Early arthritis Sulfur Follow-Up Studies |
| Zdroj: | British journal of rheumatology. 31(7) |
| ISSN: | 0263-7103 |
| Popis: | A minority of individuals have an impaired ability to oxidize sulphur. An increased prevalence of this poor S-oxidation capacity has been observed in patients with established rheumatoid arthritis (RA). The role of this enzyme system in the development of disease was studied by testing the S-oxidation capacity of 54 patients with recent onset symmetrical poly-arthritis, who were followed up at 1 and 4 years. Those patients with persistent disease at 1 year had a prevalence of poor S-oxidation of 69%. At 4 years 74% of those with a diagnosis of RA were poor S-oxidizers compared to 31% of those who were asymptomatic (P less than 0.01). A defective ability to oxidize sulphur appears to predispose to persistent clinical disease. |
| Databáze: | OpenAIRE |
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