Pattern of endogenous lectins of a human sarcoma (Ewing's sarcoma) reveals differences to human normal tissues and tumors of epithelial and germ cell origin
| Autor: | Reinhild Engelhardt, David J. Sartoris, Friedrich Cramer, H. J. Gabius |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Endogeny Sarcoma Ewing Chromatography Affinity Affinity chromatography Bone Marrow Lectins medicine Carcinoma Humans chemistry.chemical_classification biology Teratoma Lectin medicine.disease Molecular biology Molecular Weight medicine.anatomical_structure Oncology chemistry biology.protein Apudoma Electrophoresis Polyacrylamide Gel Sarcoma Glycoprotein Germ cell |
| Zdroj: | Cancer Letters. 31:139-145 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(86)90004-2 |
| Popis: | A human sarcoma, Ewing's sarcoma, contains activities of endogenous lectins. Fractionation of salt and detergent extracts by affinity chromatography on columns with immobilized sugars or glycoproteins results in the pattern of endogenous lectins for alpha- and beta-galactosides, alpha-mannosyl- and alpha-fucosyl-moieties. Whereas some lectins are known from normal, non-malignant human tissues or from a human epithelial tumor or a human germ cell tumor, a Ca2+-independent alpha- and beta-galactoside-binding protein at apparent molecular weight of 58 kilodaltons has so far not been characterized from any human source. The patterns for the tumors and human normal tissues reveal various differences in comparison between each other. These differences, documented for the first human sarcoma, human tumors of different histogenetic lineage and normal tissues are a first step to a lectin-based diagnosis and therapy of certain human cancer types. |
| Databáze: | OpenAIRE |
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