Circuit asymmetries underlie functional lateralization in the mouse auditory cortex
| Autor: | Hysell V. Oviedo, Tiemo Marquarding, Nicolas Renier, Robert B. Levy, Ashlan P. Reid, Christopher M. Pun |
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| Přispěvatelé: | The City College of New York (CCNY), City University of New York [New York] (CUNY), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, Hal Sorbonne Université, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Auditory perception Male Science General Physics and Astronomy 02 engineering and technology Biology Auditory cortex General Biochemistry Genetics and Molecular Biology Lateralization of brain function Functional Laterality Article 03 medical and health sciences Mice Gene expression analysis Animals lcsh:Science Auditory Cortex Multidisciplinary Social communication Extramural [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences General Chemistry Functional lateralization 021001 nanoscience & nanotechnology Cellular neuroscience 030104 developmental biology Acoustic Stimulation Brain size Auditory Perception Mice Inbred CBA Cortex Auditory system lcsh:Q 0210 nano-technology Neuroscience [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) Nature Communications, Nature Publishing Group, 2019, 10, pp.2783. ⟨10.1038/s41467-019-10690-3⟩ Nature Communications, 2019, 10, pp.2783. ⟨10.1038/s41467-019-10690-3⟩ |
| ISSN: | 2041-1723 |
| Popis: | The left hemisphere’s dominance in processing social communication has been known for over a century, but the mechanisms underlying this lateralized cortical function are poorly understood. Here, we compare the structure, function, and development of each auditory cortex (ACx) in the mouse to look for specializations that may underlie lateralization. Using Fos brain volume imaging, we found greater activation in the left ACx in response to vocalizations, while the right ACx responded more to frequency sweeps. In vivo recordings identified hemispheric differences in spectrotemporal selectivity, reinforcing their functional differences. We then compared the synaptic connectivity within each hemisphere and discovered lateralized circuit-motifs that are hearing experience-dependent. Our results suggest a specialist role for the left ACx, focused on facilitating the detection of specific vocalization features, while the right ACx is a generalist with the ability to integrate spectrotemporal features more broadly. The left hemisphere of the brain is especially involved in processing social vocalizations and (in humans) language, but the mechanisms of this lateralization of function are unclear. Here, the authors compared left and right auditory cortex in mice and show lateralized, experience-dependent circuit-motifs. |
| Databáze: | OpenAIRE |
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