Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation
| Autor: | C. Lacombe, Serge Adnot, Laurent Belhassen, Saı̈d Sediame, C. Bucherer, Frédéric Galactéros, Gabriel Pelle, Claudine Carville, Dora Bachir |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Endothelium Adolescent Brachial Artery Immunology Blood viscosity Vasodilation Anemia Sickle Cell Nitric Oxide Biochemistry Internal medicine medicine Humans Endothelial dysfunction Ultrasonography omega-N-Methylarginine business.industry Cell Biology Hematology medicine.disease Sickle cell anemia Acetylcholine Oxygen Plethysmography medicine.anatomical_structure Regional Blood Flow Case-Control Studies Cardiology Omega-N-Methylarginine Female Endothelium Vascular Stress Mechanical medicine.symptom Nitric Oxide Synthase business Vaso-occlusive crisis Vasoconstriction |
| Zdroj: | Blood. 97(6) |
| ISSN: | 0006-4971 |
| Popis: | Interactions between the endothelium and erythrocytes may contribute to the vascular complications of sickle cell disease (SCD). Endothelium-derived nitric oxide (NO) plays a major role in the regulation of vasomotor tone in response to wall shear stress (WSS) variations and pharmacologic stimuli. However, little is known about endothelial NO production in patients with steady-state SCD. We investigated endothelial NO production in response to flow or vasoactive agonists in 16 homozygous patients with steady-state SCD and 15 controls. Flow-mediated dilation (FMD), arterial diameter changes in response to 100% oxygen inhalation, blood viscosity, and calculated WSS were determined in all patients and controls. At baseline, WSS was higher in SCD patients than in controls, whereas arterial diameter was similar. In patients with SCD, FMD was impaired (1.73% ± 0.44% vs 3.97% ± 0.24% in the controls, P |
| Databáze: | OpenAIRE |
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