Epidemiology of invasive group A streptococcal infections in Norway 2010-2014: A retrospective cohort study

Autor: Hans Blystad, U. Naseer, Dominique A. Caugant, Martin Steinbakk
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.disease_cause
0302 clinical medicine
Epidemiology
Genotype
Cluster Analysis
030212 general & internal medicine
Child
Aged
80 and over
Streptococcus
Norway
Incidence
General Medicine
Middle Aged
Anti-Bacterial Agents
Infectious Diseases
Child
Preschool
Female
medicine.drug
Bacterial Outer Membrane Proteins
Microbiology (medical)
Adult
medicine.medical_specialty
Adolescent
Streptococcus pyogenes
030106 microbiology
Necrotising fasciitis
Erythromycin
Biology
03 medical and health sciences
Young Adult
Internal medicine
Streptococcal Infections
Drug Resistance
Bacterial
medicine
Humans
Aged
Retrospective Studies
Antigens
Bacterial
Molecular epidemiology
Infant
Newborn
Genetic Variation
Infant
medicine.disease
Immunology
Multilocus sequence typing
Carrier Proteins
Multilocus Sequence Typing
Zdroj: European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 35(10)
ISSN: 1435-4373
Popis: Streptococcus pyogenes or group A streptococcus (GAS) causes mild to severe infections in humans. GAS genotype emm1 is the leading cause of invasive disease worldwide. In the Nordic countries emm28 has been the dominant type since the 1980s. Recently, a resurgence of genotype emm1 was reported from Sweden. Here we present the epidemiology of invasive GAS (iGAS) infections and their association with emm-types in Norway from 2010–2014. We retrospectively collected surveillance data on antimicrobial susceptibility, multilocus sequence type and emm-type, and linked them with demographic and clinical manifestation data to calculate age and sex distributions, major emm- and sequence types and prevalence ratios (PR) on associations between emm-types and clinical manifestations. We analysed 756 iGAS cases and corresponding isolates, with overall incidence of 3.0 per 100000, median age of 59 years (range, 0–102), and male 56 %. Most frequent clinical manifestation was sepsis (49 %) followed by necrotizing fasciitis (9 %). Fifty-two different emm-types and 67 sequence types were identified, distributed into five evolutionary clusters. The most prevalent genotype was emm1 (ST28) in all years (range, 20–33 %) followed by 15 % emm28 in 2014. All isolates were susceptible to penicillin, 15 % resistant to tetracycline and
Databáze: OpenAIRE
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