Epidemiology of invasive group A streptococcal infections in Norway 2010-2014: A retrospective cohort study
Autor: | Hans Blystad, U. Naseer, Dominique A. Caugant, Martin Steinbakk |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male medicine.disease_cause 0302 clinical medicine Epidemiology Genotype Cluster Analysis 030212 general & internal medicine Child Aged 80 and over Streptococcus Norway Incidence General Medicine Middle Aged Anti-Bacterial Agents Infectious Diseases Child Preschool Female medicine.drug Bacterial Outer Membrane Proteins Microbiology (medical) Adult medicine.medical_specialty Adolescent Streptococcus pyogenes 030106 microbiology Necrotising fasciitis Erythromycin Biology 03 medical and health sciences Young Adult Internal medicine Streptococcal Infections Drug Resistance Bacterial medicine Humans Aged Retrospective Studies Antigens Bacterial Molecular epidemiology Infant Newborn Genetic Variation Infant medicine.disease Immunology Multilocus sequence typing Carrier Proteins Multilocus Sequence Typing |
Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 35(10) |
ISSN: | 1435-4373 |
Popis: | Streptococcus pyogenes or group A streptococcus (GAS) causes mild to severe infections in humans. GAS genotype emm1 is the leading cause of invasive disease worldwide. In the Nordic countries emm28 has been the dominant type since the 1980s. Recently, a resurgence of genotype emm1 was reported from Sweden. Here we present the epidemiology of invasive GAS (iGAS) infections and their association with emm-types in Norway from 2010–2014. We retrospectively collected surveillance data on antimicrobial susceptibility, multilocus sequence type and emm-type, and linked them with demographic and clinical manifestation data to calculate age and sex distributions, major emm- and sequence types and prevalence ratios (PR) on associations between emm-types and clinical manifestations. We analysed 756 iGAS cases and corresponding isolates, with overall incidence of 3.0 per 100000, median age of 59 years (range, 0–102), and male 56 %. Most frequent clinical manifestation was sepsis (49 %) followed by necrotizing fasciitis (9 %). Fifty-two different emm-types and 67 sequence types were identified, distributed into five evolutionary clusters. The most prevalent genotype was emm1 (ST28) in all years (range, 20–33 %) followed by 15 % emm28 in 2014. All isolates were susceptible to penicillin, 15 % resistant to tetracycline and |
Databáze: | OpenAIRE |
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