Thymic regulation of brain cortex beta-adrenoceptors during development and aging
| Autor: | Lucio Piantanelli, Simonetta Gentile, C. Viticchi, Patrizia Fattoretti |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cerebral Cortex
Mice Inbred BALB C Aging medicine.medical_specialty Health (social science) Brain cortex Mice Nude Thymus Gland Beta adrenoceptor Mice medicine.anatomical_structure Endocrinology Cerebral cortex Internal medicine Receptors Adrenergic beta Dihydroalprenolol medicine Animals β adrenergic receptor Geriatrics and Gerontology Receptor Psychology Gerontology Neuroscience |
| Zdroj: | Archives of Gerontology and Geriatrics. 4:179-185 |
| ISSN: | 0167-4943 |
| Popis: | The influence of the thymus on beta-adrenoceptors has been studied in the brain cortex of mice during developing and aging. Affinity of beta-adrenoceptors shows no statistically significant changes in the various animal models investigated. Receptor density shows a fall in both athymic nude mice and in old normal mice. Receptor density, in particular, decreases progressively with advancing age. It has been demonstrated that thymus exerts a regulatory role in both development and aging, as a neonatal thymic graft is capable of reversing the receptor impairments found in young athymic nude mice and in old normal mice. |
| Databáze: | OpenAIRE |
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