WalK, the path towards new antibacterials with low potential for resistance development
| Autor: | Alberto Marina, Jerry M. Wells, Agnieszka E. Bem, Nadya Velikova, Peter van Baarlen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
signal-transduction
medicine.drug_class Antibiotics Computational biology Biology system Bioinformatics Biochemistry 03 medical and health sciences Drug Discovery BACTERIAL INFECTIOUS DISEASES inhibitors medicine Host-Microbe Interactomics genes 030304 developmental biology 0303 health sciences Resistance development 030306 microbiology Organic Chemistry histidine kinase 3. Good health streptococcus-pneumoniae WIAS discovery |
| Zdroj: | ACS Medicical Chemistry Letters, 4(10), 891-894 ACS Medicical Chemistry Letters 4 (2013) 10 |
| ISSN: | 1948-5875 |
| Popis: | Resistance to antibiotics used in the treatment of bacterial infectious diseases is a global health problem. More than a decade ago, two-component systems such as WalKR were proposed as ideal targets for the development of new antibiotics. Biochemical screens for WalKR inhibitors using compound libraries have identified many hits, some of which were shown to have non-specific effects. The recently published structures of the S. mutans and B. subtilis WalK provide the opportunity to study inhibitors of WalK autophosphorylation at the atomic level and means to design compounds with improved specificity and affinity using a structure-based approach. |
| Databáze: | OpenAIRE |
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