Cajal Cell Counts are Important Predictors of Outcomes in Drug Refractory Gastroparesis Patients With Neurostimulation
| Autor: | Yana Nikitina, Archana Kedar, Charu Subramony, Thomas L. Abell, Harsha S. Nagarajarao, Endashaw Omer, Vetta Vedanarayanan, Christopher J. Lahr |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroparesis medicine.medical_treatment Gastric motility Electric Stimulation Therapy Gastroenterology 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine medicine Humans Neurostimulation Peristalsis Gastrointestinal tract Gastric emptying business.industry digestive oral and skin physiology Interstitial Cells of Cajal medicine.disease Symptomatic relief digestive system diseases Interstitial cell of Cajal Treatment Outcome Gastric Emptying 030220 oncology & carcinogenesis symbols Female 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Clinical Gastroenterology. 53:366-372 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0000000000001025 |
| Popis: | BACKGROUND AND AIMS Cajal cells serve as the pacemaker cells of the gastrointestinal tract and regulates peristalsis. On the baisis of that fact, it has been hypothesized that a decrease in Cajal cells can lead to gastroparesis and other motility issues. Treatment with medications has a limited efficacy and most resort to gastric electrical stimulation (GES) devices for symptomatic relief. We believe that the number of Cajal cells present is directly proportional to symptomatic relief with GES. MATERIALS AND METHODS Twenty-three (white female) subjects were recruited from the gastric motility clinic University of Mississipi for this study with the criteria of drug refractory gastropersis. Symptoms were measured using Likert scale and gastric emptying times were measured pre-GES and post-GES. Serosal electrogram measurements were recorded during surgical placement of permanent electrical stimulator under various modes. Cajal cell count scoring via immunohistochemistry were performed during the implantaion of the GES. RESULTS The data were grouped in 2 categories based on the Cajal cells that is ≥2.00 and |
| Databáze: | OpenAIRE |
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