Protective function of human milk: The milk fat globule
| Autor: | Margrit Hamosh, Martine Armand, R L Ceriani, Paul Hamosh, Radwin Kiwan, Jerry A. Peterson, Ciaran D. Scallan, Theresa R. Henderson, Nifin R. Mehta |
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| Přispěvatelé: | Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
030309 nutrition & dietetics
03 medical and health sciences chemistry.chemical_compound Pepsin Humans Gastric lipase Food science Infant Nutritional Physiological Phenomena Triglycerides ComputingMilieux_MISCELLANEOUS Glycoproteins 030304 developmental biology Lactadherin 2. Zero hunger 0303 health sciences Milk Human biology Triglyceride Cholesterol Mucin Infant Newborn Proteolytic enzymes Obstetrics and Gynecology Lipid Droplets Anti-Bacterial Agents 3. Good health Microscopy Electron Membrane glycoproteins Biochemistry chemistry Pediatrics Perinatology and Child Health biology.protein Glycolipids [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Seminars in Perinatology Seminars in Perinatology, WB Saunders, 1999, 23 (3), pp.242-249. ⟨10.1016/S0146-0005(99)80069-X⟩ Seminars in Perinatology, 1999, 23 (3), pp.242-249. ⟨10.1016/S0146-0005(99)80069-X⟩ |
| ISSN: | 0146-0005 |
| DOI: | 10.1016/S0146-0005(99)80069-X⟩ |
| Popis: | Human milk contains many components that protect the newborn against infection at a time when the infant's own defense mechanisms are poorly developed. Fat is one of the major nutrients in human milk. The fat is contained within milk fat globules composed of a core of triglyceride and a membrane consisting of phospholipids, cholesterol, proteins, and glycoproteins. Both the membrane and the core components can provide protection against microorganisms. The major protective membrane glycoproteins, mucin, and lactadherin are resistant to conditions in the newborn's stomach and maintain their structure and function even at low pH and in the presence of the proteolytic enzyme pepsin. The core triglycerides upon hydrolysis by digestive lipases (especially gastric lipase, which is well developed in the newborn) produce free fatty acids and monoglycerides, amphiphylic substances able to lyse enveloped viruses, bacteria, and protozoa. Therefore, in addition to its nutritional value, the fat in human milk has a major protective function. |
| Databáze: | OpenAIRE |
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