Point-of-Care Testing—The Key in the Battle against SARS-CoV-2 Pandemic
| Autor: | Mariana Carmen Chifiriuc, Ciprian Iliescu, Ana Maria Ionescu, Monica Simion, Florina S. Iliescu, Larisa Gogianu, Violeta Dediu, Gratiela Gradisteanu Pircalabioru |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
SARS-CoV-2 variants point of care testing Isolation (health care) Computer science Mechanical Engineering Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Point-of-care testing detection Gold standard (test) Disease Review epidemic Control and Systems Engineering Pandemic medicine Key (cryptography) TJ1-1570 Infection control Mechanical engineering and machinery Electrical and Electronic Engineering Intensive care medicine |
| Zdroj: | Micromachines, Vol 12, Iss 1464, p 1464 (2021) Micromachines |
| Popis: | The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis. |
| Databáze: | OpenAIRE |
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