Medical cannabis treatment for chronic pain: Outcomes and prediction of response
| Autor: | Simon Vulfsons, Yelena Vysotski, Itay Goor-Aryeh, Refael Segal, Miriam Ogintz, Bareket Schiff-Keren, Tamar Gershoni, Vadim Tashlykov, David Meiri, Leslie Green, Elon Eisenberg, Yacov Fogelman, Ben Yellin, Dorit Pud, Dror Robinson, Ruth Goor, Joshua Aviram, Ofir Morag, Howard Amital, Tamar Yashar, Haim-Moshe Adahan, Oren Tsvieli, Roee Sheinfeld, Silviu Brill |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Medical Marijuana law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Mass index 030212 general & internal medicine Prospective Studies Israel Prospective cohort study Adverse effect Cannabis biology business.industry Chronic pain biology.organism_classification medicine.disease Anesthesiology and Pain Medicine Neuropathic pain Morphine Chronic Pain business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European journal of pain (London, England)REFERENCES. 25(2) |
| ISSN: | 1532-2149 |
| Popis: | BACKGROUND Although studied in a few randomized controlled trials, the efficacy of medical cannabis (MC) for chronic pain remains controversial. Using an alternative approach, this multicentre, questionnaire-based prospective cohort was aimed to assess the long-term effects of MC on chronic pain of various aetiologies and to identify predictors for MC treatment success. METHODS Patients with chronic pain, licensed to use MC in Israel, reported weekly average pain intensity (primary outcome) and related symptoms before and at 1, 3, 6, 9 and 12 months following MC treatment initiation. A general linear model was used to assess outcomes and identify predictors for treatment success (≥30% reduction in pain intensity). RESULTS A total of 1,045 patients completed the baseline questionnaires and initiated MC treatment, and 551 completed the 12-month follow-up. At 1 year, average pain intensity declined from baseline by 20% [-1.97 points (95%CI = -2.13 to -1.81; p |
| Databáze: | OpenAIRE |
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