Changes in blood glucose as a function of body temperature in laboratory mice: implications for daily torpor
| Autor: | Viviana Lo Martire, Mark J. Bingaman, Steven J. Swoap, Giovanna Zoccoli, Alessandro Silvani, Alice Valli |
|---|---|
| Přispěvatelé: | Lo Martire V, Valli A, Bingaman M, Zoccoli G, Silvani A, Swoap S |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hibernation Blood Glucose Male medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Torpor macromolecular substances Biology Body Temperature Feeding Methods 03 medical and health sciences Eating Mice Physiology (medical) Internal medicine medicine Animals Telemetry glucose hibernation Caloric Restriction Laboratory mouse Caloric theory Fasting carbohydrates (lipids) Mice Inbred C57BL 030104 developmental biology Endocrinology lipids (amino acids peptides and proteins) Research Article |
| Popis: | Many small mammals, such as the laboratory mouse, utilize the hypometabolic state of torpor in response to caloric restriction. The signals that relay the lack of fuel to initiate a bout of torpor are not known. Because the mouse will only enter a torpid state when calorically challenged, it may be that one of the inputs for initiation into a bout of torpor is the lack of the primary fuel (glucose) used to power brain metabolism in the mouse. Using glucose telemetry in mice, we tested the hypotheses that 1) circulating glucose (GLC), core body temperature (Tb), and activity are significantly interrelated; and 2) that the level of GLC at the onset of torpor differs from both GLC during arousal from torpor and during feeding when there is no torpor. To test these hypotheses, six C57Bl/6J mice were implanted with glucose telemeters and exposed to different feeding conditions (ad libitum, fasting, limited food intake, and refeeding) to create different levels of GLC and Tb. We found a strong positive and linear correlation between GLC and Tb during ad libitum feeding. Furthermore, mice that were calorically restricted entered torpor bouts readily. GLC was low during torpor entry but did not drop precipitously as Tb did at the onset of a torpor bout. GLC significantly increased during arousal from torpor, indicating the presence of endogenous glucose production. While low GLC itself was not predictive of a bout of torpor, hyperactivity and low GLC preceded the onset of torpor, suggesting that this may be involved in triggering torpor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|