Left ventricular endocardial and epicardial strain changes with apical myocardial ischemia in an open-chest porcine model
| Autor: | Aman Mahajan, Melissa McCabe, Einat Mazor, Wei Zhou, Alexander Cheng, Kentaro Yamakawa, Kimberly Howard-Quijano, Jennifer Scovotti |
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| Rok vydání: | 2016 |
| Předmět: |
Cardiovascular Conditions
Disorders and Treatments medicine.medical_specialty Myocardial ischemia Physiology Swine Ischemia Myocardial Ischemia Strain (injury) Blood Pressure ischemia 030204 cardiovascular system & hematology Anterior Descending Coronary Artery 03 medical and health sciences Ventricular Dysfunction Left left ventricular function 0302 clinical medicine strain Heart Rate Physiology (medical) Internal medicine Occlusion Medicine Animals 030212 general & internal medicine cardiovascular diseases Endocardium Original Research Ejection fraction business.industry Heart medicine.disease Biomechanical Phenomena Disease Models Animal Echocardiography Cardiology business Radial stress |
| Zdroj: | Physiological Reports |
| ISSN: | 2051-817X |
| Popis: | Early detection of acute myocardial ischemia is critical to prevent permanent myocardial damage. The impact of apical ischemia on global left ventricular (LV) function can be difficult to characterize using traditional volume‐based echocardiography measures. Myocardial strain imaging is a sensitive, quantitative marker of myocardial deformation that can measure ventricular function. Recent advances allow layer‐specific measurement of endo‐ and epicardial strain, enhancing the ability to evaluate myocardial ischemia. This study investigates the effects of apical ischemia on LV function using epi‐ and endocardial strain. We hypothesize that myocardial strain will identify changes in regional and global myocardial function associated with focal apical ischemia as compared to ejection fraction (EF), and that longitudinal strain will be a better indicator of myocardial dysfunction compared to circumferential or radial strain. In a porcine model (n = 9), acute ischemia was induced by left anterior descending coronary artery occlusion. Echocardiograms were performed at baseline, during 15‐min ischemia, and after reperfusion. Global longitudinal strain decreased with acute focal ischemia of the left ventricular apical region (baseline: −16.4% vs. ischemia: −12.2%; P = 0.010), with no change observed in global circumferential and radial strain or EF. Both endocardial and epicardial longitudinal strain decreased by 68% (P |
| Databáze: | OpenAIRE |
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