The clinical phenotype of Graves’ disease occurring as an isolated condition or in association with other autoimmune diseases
| Autor: | Mario Rotondi, Camilla Virili, Laura Croce, Nunzia Brusca, Luca Chiovato, Marco Centanni, Francesca Coperchini, Sara M. A. Pinto |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Graves' disease 030209 endocrinology & metabolism Physical examination Trab Disease Immunoglobulin D Gastroenterology Autoimmune Diseases thyroid 03 medical and health sciences 0302 clinical medicine Endocrinology Hypothyroidism Internal medicine medicine Humans hyperthyroidism Retrospective Studies Autoimmune poliglandular syndromes Graves’ disease medicine.diagnostic_test biology urogenital system business.industry Thyroid Middle Aged medicine.disease Graves Disease Graves Ophthalmopathy Phenotype medicine.anatomical_structure Italy 030220 oncology & carcinogenesis biology.protein Female Thyroglobulin Thyroid function business |
| Zdroj: | Journal of Endocrinological Investigation. 43:157-162 |
| ISSN: | 1720-8386 |
| Popis: | Graves’ disease (GD) can present as an isolated disease (iGD) or in association with other autoimmune diseases (aGD). The aim of this study, performed in two Endocrine referral centers settled in different geographical areas of Italy, was to compare the anthropometric, clinical, and biochemical phenotype of iGD patients with that of the aGD ones. Clinical history, physical examination data, serum levels of TSH, FT4, FT3, thyroglobulin (TgAb), thyroid-peroxidase (TPOAb) and TSH-receptor (TRAb) antibody, presence of Graves’ orbitopathy (GO), and thyroid ultrasound examination at disease diagnosis were recorded. 68 aGD and 136 iGD patients were consecutively recruited. At diagnosis, aGD and iGD patients did not differ for F/M ratio, age at presentation, thyroid function parameters, serum levels of TRAb, TgAb, TPOAb, presence of GO, and thyroid volume. The serum levels of TRAb were strongly correlated with the circulating concentrations of both FT3 (ρ = 0.667; p |
| Databáze: | OpenAIRE |
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