| Autor: |
Zhan Li, Yin Li, Qingjiang Li, Fang-Hai Tu, Shuang Yang, Honggen Wang, Dong-Hang Tan |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.26434/chemrxiv-2021-xl67g-v2 |
| Popis: |
The gem-difluoroalkanes widely exist in pharmaceuticals, agrochemicals and materials. Reported herein is a facile synthesis of tosyloxylated gem-difluoroalkanes via an oxidative fluorination of readily available vinyl sulfonates. An intriguing [2,3]-sulfonyloxy migration is involved as a key step. The OTs group in the product enables a divergent and modular synthesis of a wide variety of functionalized gem-difluoroalkanes via reliable SN2 reactions. Notable features of this protocol include mild reaction conditions, high efficiency and remarkably good functional-group tolerance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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