Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis
| Autor: | Nicole Moreau, Hélène Cousin, Alban Gaultier, Dominique Alfandari, Thierry Darribère |
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| Rok vydání: | 2003 |
| Předmět: |
DNA
Complementary animal structures Molecular Sequence Data Xenopus Xenopus laevis Sequence Analysis Protein Notochord Genetics medicine Dystroglycan Animals Amino Acid Sequence Cloning Molecular Dystroglycans In Situ Hybridization Membrane Glycoproteins biology Gene Expression Regulation Developmental biology.organism_classification Molecular biology Pronephros Gastrulation Cytoskeletal Proteins Neurulation medicine.anatomical_structure embryonic structures biology.protein Otic vesicle Endoderm Sequence Alignment Developmental Biology |
| Zdroj: | Development Genes and Evolution. 213:355-359 |
| ISSN: | 1432-041X 0949-944X |
| DOI: | 10.1007/s00427-003-0328-6 |
| Popis: | Dystroglycan is a cell surface receptor involved in the pathogenesis of muscular dystrophy, and plays a critical role in the assembly and homeostasis of basement membranes. Since data about the amphibian homologue are limited, we have cloned the full-length dystroglycan cDNAs from the frog Xenopus laevis. Using in situ hybridization, we show that mRNA expression is dynamic, particularly in the notochord at the end of gastrulation and during neurulation, suggesting that the protein might play unexplored roles in the specification and/or formation of this tissue. Subsequently, the transcripts are detected in the otic vesicle, the developing brain, and in mesenchymal cells of the visceral arches, as well as in pharyngeal endoderm, the pronephros, pronephric ducts, proctodaeum and the somites. |
| Databáze: | OpenAIRE |
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