The role of hepatitis B infection in anti-tuberculosis drug-induced liver injury: a meta-analysis of cohort studies
| Autor: | Xiaoling Cai, Yun-Li Wu, Mei-Hong Guo, Hewei Peng, Xian-E Peng, Jing Zheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tuberculosis Epidemiology 030106 microbiology Antitubercular Agents medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Hepatitis B virus Original Paper business.industry Coinfection medicine.disease Hepatitis B hepatitis B infection Infectious Diseases HBeAg Relative risk Meta-analysis Liver function Chemical and Drug Induced Liver Injury Anti-tuberculosis business Adverse drug reaction Cohort study liver injury |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 |
| Popis: | Drug-induced liver injury (DILI) is a common adverse drug reaction leading to the interruption of tuberculosis (TB) therapy. We aimed to identify whether the hepatitis B virus (HBV) infection would increase the risk of DILI during first-line TB treatment. A meta-analysis of cohort studies searched in PubMed, Web of Science and China National Knowledge Infrastructure was conducted. Effect sizes were reported as risk ratios (RRs) and 95% confidence intervals (CIs) and calculated by R software. Sixteen studies with 3960 TB patients were eligible for analysis. The risk of DILI appeared to be higher in TB patients co-infected with HBV (RR 2.66; 95% CI 2.13–3.32) than those without HBV infection. Moreover, patients with positive hepatitis B e antigen (HBeAg) were more likely to develop DILI (RR 3.42; 95% CI 1.95–5.98) compared to those with negative HBeAg (RR 2.30; 95% CI 1.66–3.18). Co-infection with HBV was not associated with a higher rate of anti-TB DILI in latent TB patients (RR 4.48; 95% CI 0.80–24.99). The effect of HBV infection on aggravating anti-TB DILI was independent of study participants, whether they were newly diagnosed with TB or not. Besides, TB and HBV co-infection patients had a longer duration of recovery from DILI compared to non-co-infected patients (SMD 2.26; 95% CI 1.87–2.66). To conclude, the results demonstrate that HBV infection would increase the risk of DILI during TB therapy, especially in patients with positive HBeAg, and close liver function monitoring is needed for TB and HBV co-infection patients. |
| Databáze: | OpenAIRE |
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