Cost-Effectiveness of LTBI Treatment for TB Contacts in British Columbia
| Autor: | Mohsen Sadatsafavi, Fawziah Marra, J. Mark FitzGerald, Onofre Morán-Mendoza, R. Kevin Elwood, Carlo A. Marra, Susanne Moadebi, Michael C. Tan |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Tuberculosis Adolescent diagnosis Cost effectiveness Antitubercular Agents Tuberculin Sensitivity and Specificity contact tracing Young Adult Ltbi treatment Risk Factors Active tb Humans Medicine Young adult Child Tuberculosis Pulmonary tuberculin test British Columbia business.industry cost-benefit analysis Health Policy Infant Newborn Public Health Environmental and Occupational Health Infant bacterial infections and mycoses medicine.disease Markov Chains Quality-adjusted life year Surgery Models Economic tuberculosis Child Preschool Female Quality-Adjusted Life Years business Contact tracing |
| Zdroj: | Value in Health. 11(5):842-852 |
| ISSN: | 1098-3015 |
| DOI: | 10.1111/j.1524-4733.2008.00334.x |
| Popis: | BackgroundContacts of patients with active tuberculosis (“TB contacts”) with a tuberculin skin test (TST) size ≥5 mm are currently recommended treatment for latent TB infection (LTBI). Knowing the cost-effectiveness of LTBI therapy for specific TB contact subpopulations may improve the use of limited resources by reducing the treatment of persons at low TB risk.ObjectiveTo evaluate the cost-effectiveness of LTBI therapy for different TB contact populations defined by important risk factors, and to propose an optimal policy based on different recommendation for each subgroup of contacts.MethodsA 6-year Markov decision analytic model simulating the quality-adjusted life years (QALYs), number of active TB cases prevented, and costs for hypothetical cohorts of Canadian TB contacts defined by TST size, age group ( |
| Databáze: | OpenAIRE |
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