Adenocarcinoma With Breast/Adnexal and Upper Gastrointestinal Differentiation Arising in an Ovarian Mature Cystic Teratoma
| Autor: | Lindsay J. Wheeler, Gina L. Westhoff, Amer Karam, Christina S. Kong, Mary C. O'Keefe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Skin Neoplasms Paclitaxel Antineoplastic Agents Breast Neoplasms Adenocarcinoma Neuroendocrine differentiation Pathology and Forensic Medicine Malignant transformation 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Humans Medicine Upper gastrointestinal Gastrointestinal Neoplasms Ovarian Neoplasms 030219 obstetrics & reproductive medicine business.industry Teratoma Obstetrics and Gynecology Histology Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Cell Transformation Neoplastic Treatment Outcome 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Germ cell tumors Cisplatin business |
| Zdroj: | International Journal of Gynecological Pathology. 35:72-77 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/pgp.0000000000000218 |
| Popis: | Mature cystic teratomas are the most common type of ovarian germ cell tumors. In about 1% of cases, usually among postmenopausal women, a mature cystic teratoma can undergo malignant transformation. Among malignant transformations, squamous cell carcinoma is the most common histology, comprising approximately 80% of cases. In this report, we present the unique case of a 55-yr-old woman with a pelvic mass found to be a mature cystic teratoma with malignant transformation to adenocarcinoma with breast/adnexal, upper gastrointestinal, and neuroendocrine differentiation. The predominant malignant component was the adenocarcinoma exhibiting breast/skin adnexal differentiation, which was found to involve the omentum and a right para-aortic node. We provide an in-depth review of the pathologic findings, as well as a review of the current literature on malignant transformation to adenocarcinoma. This report aims to open a conversation regarding the management of these patients, with a specific focus on the role of molecular analysis and targeted therapies. |
| Databáze: | OpenAIRE |
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