Quantification of structural changes in the corpus callosumin children with profound hypoxic–ischaemic brain injury
| Autor: | Nigel Hoggard, Ann Gledson, Mark Radon, John A. Keane, Paul D. Griffiths, Neville B. Wright, Reneta Mileva, Patricia E. Cowell, Ruth Batty, Vivian Tang, Daniel J.A. Connolly, Stavros Stivaros |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Nervous system
Male Pathology medicine.medical_specialty Adolescent Corpus callosum Hypoxic ischaemic brain injury Central nervous system Ischemia Hypoxic–ischaemic brain injury Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Age groups 030225 pediatrics medicine Humans Radiology Nuclear Medicine and imaging Pediatrics Perinatology and Child Health Child Children Neuroradiology business.industry Infant Reproducibility of Results medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Radiology Nuclear Medicine and imaging Blood circulation Child Preschool Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain Original Article Female Support vector machine analysis business 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Radiology |
| ISSN: | 1432-1998 0301-0449 |
| Popis: | Background Birth-related acute profound hypoxic–ischaemic brain injury has specific patterns of damage including the paracentral lobules. Objective To test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality. Materials and methods Study subjects included 13 children with proven acute profound hypoxic–ischaemic brain injury and 13 children with developmental delay but no brain abnormalities. A computerised system divided the corpus callosum into 100 segments, measuring each width. Principal component analysis grouped the widths into contiguous anatomical regions. We conducted analysis of variance of corpus callosum widths as well as support vector machine stratification into patient groups. Results There was statistically significant narrowing of the mid–posterior body and genu of the corpus callosum in children with hypoxic–ischaemic brain injury. Support vector machine analysis yielded over 95% accuracy in patient group stratification using the corpus callosum centile widths. Conclusion Focal volume loss is seen in the corpus callosum of children with hypoxic–ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules. Support vector machine stratification into the hypoxic–ischaemic brain injury group or the control group on the basis of corpus callosum width is highly accurate and points towards rapid clinical translation of this technique as a potential biomarker of hypoxic–ischaemic brain injury. |
| Databáze: | OpenAIRE |
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