Effect of Per Os Administration of Mercuric Chloride on Peroxidation Processes in Japanese Quail
| Autor: | Z. Faixová, Š. Faix, J. Varady, E. Michnová |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Kidney lcsh:Veterinary medicine Antioxidant General Veterinary biology Chemistry Thiobarbituric acid medicine.medical_treatment Malondialdehyde Chloride Quail Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Endocrinology medicine.anatomical_structure Biochemistry Internal medicine biology.animal medicine biology.protein lcsh:SF600-1100 medicine.drug |
| Zdroj: | Acta Veterinaria Brno, Vol 72, Iss 1, Pp 23-26 (2003) |
| ISSN: | 1801-7576 0001-7213 |
| Popis: | Faix, ·., Z. Faixova, E. Michnova, J. Varady: Effect of Per Os Administration of Mercuric Chloride on Peroxidation Processes in Japanese Quail. Acta Vet. Brno 2003, 72: 23-26 Activities of glucose-6-phosphate dehydrogenase (G-6-PD, E.C. 1.1.1.49), superoxide dismutase (SOD, E.C. 1.15.1.1) in erythrocytes and the amount of malondialdehyde (MDA) precursors in the liver and kidney were examined in Japanese quails exposed to mercuric chloride (HgCl2) (25 mg.l -1 drinking water) for 60 days. Lipid peroxidation was determined by the thiobarbituric acid reaction measuring the production of malondialdehyde precursors and the enzymes activities were measured by the spectrophotometric methods. Lipid peroxidation measured by the quantification of MDA precursors was significantly higher in both quail organs treated with HgCl2 than in control groups (liver: 5.3 ± 0.22 in the controls vs. 16.0 ± 0.62 µmol.g-1, P < 0.001; kidney: 7.6 ± 0.21 in the controls vs. 19.0 ± 0.61 µmol.g -1 , P < 0.001 ). The activities of both SOD and G-6-PD in erythrocytes after the administration of HgCl 2 were significantly less than in the control group (G-6-PD: 59.98 ± 1.22 in the controls vs. 41.5 ± 3.19 mU.10 -9 Ec, P |
| Databáze: | OpenAIRE |
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