Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
| Autor: | Xiaowei Jiang, Yanqing Tang, Fei Wang, Fay Y. Womer, Yifang Zhou, Ke Xu, Shengnan Wei, Yuting Ye, Elliot Kale Edmiston, Miao Chang, Qian Zhou, Haiyan Huang, Xi-Nian Zuo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Brain activity and meditation Emotions Audiology 03 medical and health sciences Young Adult 0302 clinical medicine Neuroimaging medicine Limbic System Humans Pharmacology (medical) Bipolar disorder Biological Psychiatry Balance (ability) Cerebral Cortex Depressive Disorder Major Resting state fMRI Social perception Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Neostriatum Psychiatry and Mental health Cross-Sectional Studies Social Perception Schizophrenia Major depressive disorder Female Psychology human activities 030217 neurology & neurosurgery Research Paper |
| Popis: | Background: Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations have been reported in the neural system for emotional perception, but the similarities and differences in the amplitude of low-frequency fluctuation (ALFF) across the 3 disorders are unknown. Methods: We compared ALFF and its signal balance in the neural system for emotional perception at 2 frequency bands (slow-5 and slow-4) in 119 participants with schizophrenia, 100 with bipolar disorder, 123 with major depressive disorder and 183 healthy controls. We performed exploratory Pearson partial correlation analyses to determine the relationship between ALFF signal balance and clinical variables. Results: We observed commonalities in ALFF change patterns across the 3 disorders for emotional perception neural substrates, such as increased ALFF in the anterior cerebrum (including subcortical, limbic, paralimbic and heteromodal cortical regions) and decreased ALFF in the posterior visual cortices. Schizophrenia, bipolar disorder and major depressive disorder showed significantly decreased ALFF signal balance in the neural system for emotional perception at both slow-5 and slow-4 frequency bands, with the greatest alterations for schizophrenia, followed by bipolar disorder and major depressive disorder. We found a negative correlation between ALFF signal balance and negative/disorganized symptoms in slow-4 across the 3 disorders. Limitations The relatively broad age range in our sample and the cross-sectional study design may not account for our findings. Conclusion: The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder. |
| Databáze: | OpenAIRE |
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