Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene
| Autor: | D. Civitareale, Adolfo Saiardi, Maria Paola Castelli, P. Falasca |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Transcriptional Activation
endocrine system endocrine system diseases medicine.medical_treatment Molecular Sequence Data Thyroid Nuclear Factor 1 Thyroid Transcription Factor 1 Regulatory Sequences Nucleic Acid Polymerase Chain Reaction Cell Line Thyrotropin receptor Thyroid hormone receptor beta Endocrinology Thyroid peroxidase medicine Animals Promoter Regions Genetic Molecular Biology Binding Sites Thyroid hormone receptor Base Sequence biology Nuclear Proteins Cell Differentiation Receptors Thyrotropin General Medicine Molecular biology eye diseases Rats Cell biology Gene Expression Regulation biology.protein Thyroglobulin Thyroid function PAX8 hormones hormone substitutes and hormone antagonists Protein Binding Transcription Factors |
| Zdroj: | Molecular Endocrinology. 7:1589-1595 |
| ISSN: | 1944-9917 0888-8809 |
| Popis: | The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid transcription factor 1 (TTF1), a transcription factor essential for thyroid-specific gene expression, binds to the TSHr minimal promoter. The promoter, when mutated at this binding site, shows a decreased activity in thyroid cells. In cotransfection experiments in nonthyroid cells, TTF1 is able to trans-activate the TSHr minimal promoter. This finding strengthens the importance of TTF1 in the maintenance of thyroid differentiation. The promoters of the main thyroid differentiation markers thyroglobulin, thyroperoxidase, and now TSHr, are regulated by TTF1. |
| Databáze: | OpenAIRE |
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